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[1]戴书明艾俊张春傅强贾璐阎兵杜明珠.《血液储存标准》对冷沉淀和新鲜冰冻血浆解冻后储存条件修改的研究[J].中国卫生质量管理,2025,32(06):95-98.[doi:10.13912/j.cnki.chqm.2025.32.6.18]
　DAI Shuming,AI Jun,ZHANG Chun.Research on the Revision of Storage Conditions for Cryoprecipitate and Fresh Frozen Plasma after Thawing in the Blood Storage Standard[J].Chinese Health Quality Management,2025,32(06):95-98.[doi:10.13912/j.cnki.chqm.2025.32.6.18]

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《血液储存标准》对冷沉淀和新鲜冰冻血浆解冻后储存条件修改的研究

《中国卫生质量管理》[ISSN:1006-7515/CN:CN 61-1283/R] 卷: 32 期数: 2025年06期页码: 95-98 栏目: 血液质量出版日期: 2025-06-15

Title:: Research on the Revision of Storage Conditions for Cryoprecipitate and Fresh Frozen Plasma after Thawing in the Blood Storage Standard

作者:: 戴书明艾俊张春傅强贾璐阎兵杜明珠; 南京红十字血液中心

Author(s):: DAI Shuming; AI Jun; ZHANG Chun; Nanjing Red Cross Blood Center

关键词:: 血液储存标准; 冷沉淀; 新鲜冰冻血浆; 血液质量; 血液安全

Keywords:: Blood Storage Standard; Cryoprecipitate; Fresh Frozen Plasma; Blood Quality; Blood Safety

分类号:: R331.1

DOI:: 10.13912/j.cnki.chqm.2025.32.6.18

文献标志码:: A

摘要:: 目的探讨冷沉淀和新鲜冰冻血浆解冻后因储存条件修改而引起的变化，验证《血液储存标准》修改的合理性。方法随机抽取南京红十字血液中心2023年10月-2024年8月制备的冷沉淀和新鲜冰冻血浆各48袋。将冷沉淀完全解冻后分别储存于4 ℃6 h、4 ℃24 h、24 ℃6 h、24 ℃24 h条件下，比较不同条件下冷沉淀中纤维蛋白原（Fbg）、凝血因子Ⅷ（FⅧ）、凝血因子V（FV）、凝血因子Ⅱ（FⅡ）含量的变化。将新鲜冰冻血浆完全解冻后分别储存于4 ℃24 h、4 ℃120 h条件下，比较总蛋白（TP）、Fbg、FⅧ、FV、FⅡ含量的变化。结果冷沉淀解冻后分别储存于4种条件下，与初始FⅧ含量相比，4种条件下FⅧ含量均下降，4 ℃6 h、4 ℃24 h、24 ℃24 h条件下FⅧ含量与原始检测结果比较，差异均有统计学意义（P＜0.05）。新鲜冰冻血浆解冻后储存于4 ℃24 h、4 ℃120 h条件下，TP和Fbg含量与解冻后0 h相比差异均无统计学意义（P＞0.05），FⅧ、FV、FⅡ含量均下降且差异均有统计学意义（P＜0.05）。结论《血液储存标准》（WS 399-2023）修改后，冷沉淀有更好的临床疗效，新鲜冰冻血浆能在减少浪费的同时更好地用于临床治疗。

Abstract:: ObjectiveTo investigate the changes in cryoprecipitate and fresh frozen plasma (FFP) after thawing due to modified storage conditions and to validate the rationality of the revisions made to the Blood Storage Standard.MethodsA total of 48 bags each of cryoprecipitate and FFP prepared from October 2023 to August 2024 at the Nanjing Red Cross Blood Center were randomly selected. After complete thawing, cryoprecipitate was stored under four conditions: 4°C for 6 hours, 4°C for 24 hours, 24°C for 6 hours, and 24°C for 24 hours. The changes in fibrinogen (Fbg), coagulation factor VIII (FⅧ), coagulation factor V (FV), and coagulation factor II (FⅡ) content in cryoprecipitate under different conditions were compared. After complete thawing, FFP was stored at 4°C for 24 hours and 4°C for 120 hours. The changes in total protein (TP), Fbg, FⅧ, FV, and FⅡ content were compared.ResultsAfter thawing, cryoprecipitate was stored under the four conditions. Compared with the initial FⅧ content, the FⅧ content decreased under all four conditions. The differences in FⅧ content between the conditions of 4°C for 6 hours, 4°C for 24 hours, and 24°C for 24 hours and the original test results were statistically significant (P< 0.05). After thawing, FFP was stored at 4°C for 24 hours and 4°C for 120 hours. There were no statistically significant differences in TP and Fbg content compared with 0 hours after thawing (P> 0.05). The content of FⅧ, FV, and FⅡ decreased, and the differences were statistically significant (P< 0.05).Conclusion After the revision of the Blood Storage Standard (WS 399-2023), cryoprecipitate demonstrates better clinical efficacy, and FFP can be better utilized in clinical treatment while reducing waste.

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更新日期/Last Update: 2025-06-15